G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, Diffraction phase microscopy for quantifying cell structure and dynamics, Opt. Lett., 31, 775 (2006).
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We have developed diffraction phase microscopy as a new technique for quantitative phase imaging of biological structures. The method combines the principles of common path interferometry and single-shot phase imaging and is characterized by subnanometer path-length stability and millisecond-scale acquisition time. The potential of the technique for quantifying nanoscale motions in live cells is demonstrated by experiments on red blood cells.