Shamira Sridharan

Posted on March 27, 2011 by admin

 

EDUCATION

Master of Science in Bioengineering                                                               January 2011 – Present
University of Illinois at Urbana Champaign

Bachelor of Science in Bioengineering                                                          August 2006 – May 2010
University of Illinois at Urbana-Champaign
Concentration in Medical Imaging, Cognitive Psychology

RESEARCH EXPERIENCE

Quantitative Imaging Laboratory                                                                   February 2010 – Present
Graduate Research Assistant, Asst. Professor Gabriel Popescu

  • Exploring the use of optical parameters to predict recurrence of prostate cancer
  • Designing spatial spectroscopy as a technique to quantify individual component contribution (epithelium, nuclei, connective tissue) to tissue scattering spectrum and studying contribution changes with cancer progression in prostate biopsy
  • Completed a project on the characterization of optical parameters that vary in prostate cancer tissue of differing severity (Gleason Grades)
  • Set up the biology lab and started S2, HeLa cell cultures and working on fluorescent signal transduction to characterize intracellular transport
  • Worked on a project to study unlabeled intracellular transport in fibroblasts
  • Completed a project on correlation between cellular motility and cell growth

Magnetic Resonance Functional Imaging Laboratory                         June 2008 – September 2009
Undergraduate Research Assistant, Asst. Professor Bradley Sutton

  • Analyzed data from a breath-hold study to examine calibration differences due to differential oxygen absorption in the brain

Cognitive Neuroimaging Laboratory                                             February 2008 – September 2009
Undergraduate Research Assistant, Professor Monica Fabiani

  • Analyzed fMRI and optical imaging data from study on aging effects on the brain
  • Conducted EEG scans in a study on how different methods of learning affects final performance

Dr. Romana Nowak’s Laboratory                                                              May 2007 – February 2008
Undergraduate Research Assistant, Professor Romana Nowak

  • Performed immunohistochemistry experiments to characterize DDR receptor expression in human uterus and leiomyoma as well as different stages in mouse pregnancy

PAPERS

  1. Kim, T., Sridharan, S., Popescu, G. Gradient field microscopy of unstained specimens. Optics Express 20(6), 2012.
  2. Zhu, R., Sridharan, S., Tangella, K., Balla, A., Popescu, G. Correlation induced spectral changes in tissues. Optics Letters 36(21), 2011.
  3. Sridharan, S., Mir, M., Popescu, G. Simultaneous optical measurement of cell motility and growth. Biomedical Optics Express 2(1), 2011.
  4. Sridharan, S., Tapping, R., Tangella, K., Kajdacsy-Balla, A., Popescu, G. Detecting stromal changes in grade 3 and 4 prostate adenocarcinoma using SLIM. (Manuscript in preparation).

BOOK CHAPTER

  1. Kim, T., Sridharan, S., Popescu, G. Fourier transform light scattering of tissues in Coherent-domain optical methods, Second Edition, Edited by Tuchin, V.V., Springer (2012).

CONFERENCE PAPERS/POSTERS

  1. Sridharan, S., Tapping, R., Tangella, K., Kajdacsy-Balla, A., Popescu, G. SLIM as an optical tool to support pathologists in prostate diagnosis. United States and Canadian Academy of Pathology’s 101st Annual Meeting (2012). Vancouver, Canada. March 17-23, 2012.
  2. Sridharan, S., Wang, Z., Tangella, K., Kajdacsy-Balla, A., Popescu, G. Refractive Index as marker for Gleason grading of prostate cancer. College of American Pathologists (2011). Dallas, TX. September 10-14, 2011.
  3. Wang, Z., Emmadi, R., Tangella, K., Kajdacsy-Balla, A., Sridharan, S., Popescu, G. Tissue refractive index as an objective measure of pathologic processes.  International Academy of Digital Pathology (2011). Quebec, Canada. August 3-5, 2011.
  4. Wang, R., Sridharan, S., Lei, L., Wang, P., Levine, A.J., Popescu, G. Spatiotemporal transport of fluorescent markers in live cells. SPIE Photonics West (2011). San Fransisco, CA. January 22-27, 2011.
  5. Mir, M., Wang, Z., Sridharan, S., Jiang, A., Shen, Z., Bednarz,M., Blehm,B., Chaney,E., Liang,X., Boppart,S., Golding,I., Selvin,P., Prasanth,S., Popescu,G. Quantitative optical measurements of cell dry mass as a tool for studying cell growth. Annual Meeting of Strategic Initiative on Imaging (2010). Urbana, IL. October 14-15, 2010

TECHNICAL SKILLS

Programming languages: MATLAB, C.
Research Software: ImageJ, OriginPro, FSL, FreeSurfer.
Biology: Tissue sectioning, immunohistochemistry, tissue staining, cell culture techniques, sterilization methods, setting up and installing components in biology labs, preparation of media and gels, gel electrophoresis, PCR.