Diffraction Phase Microscopy (DPM)
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We have developed diffraction phase microscopy (DPM) as a new technique for quantitative phase imaging of biological structures. The method combines the principles of common path interferometry and single shot phase imaging, and is characterized by sub-nanometer path-length stability and millisecond-scale acquisition time. The potential of the technique for quantifying nanoscale motions in live cells is demonstrated by experiments on red blood cells.